The aim of the study was to prepare and characterize solid dispersion of piroxicam, a non steroidal anti inflammatory drug having low solubility. The dissolution rate of the drug enhance by using Gellucire 50/13 polymer. The solid dispersion was prepared by hot melting method at 1:1 to 1:5 drug to polymer ratios. The 1:3 ratio shows solubility increments 12.96 folds. After solubility increments batch of pellet were prepared by utilising extruder and spheronizer. The prepared solid dispersions were characterized by differential scanning calorimetry (DSC), which indicated that there were no signs of interaction of the drug with the carriers used in the case of solid dispersions containing higher polymeric contents. At start by utilising super disintegrants the rate of dissolution get increase. The motic digital microscopy images of pellets showed that the pellets have spherical shape and their size depends on the carrier used. This research concludes that the solubility of piroxicam expanded by solid dispersion method and pellets are filled into capsule form for immediate release dosage form.
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